600 mcg (1020 DFE) in Essential for Women

1000 mcg (1700 DFE) in Essential Prenatal

235 mcg (400 DFE) in Essential for Women 50+

SourcePisticci, Italy
Form5MTHF Glucosamine Salt
Found inLentils, avocado, and oranges
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DNA Synthesis*

Brain Health*

Our enzymatically active and cell-identical 5MTHF folate is the optimal form.

Works together to support heart health by adding methyl groups to homocysteine.*

+Vitamin B12


Evidence-Based or Bust

We use nutrients backed by a significant body of research that is growing every day. Of the thousands of unaffiliated studies our in-house scientists sorted through to guide our choices, the titles below are the most relevant MVPs.

Foods, fortificants, and supplements: where do Americans get their nutrients? - 2011

Nutrition Impact LLC

Neural tube defects, folic acid and methylation - 2013

VU Free University

Assessing the association between the methylenetetrahydrofolate reductase (MTHFR) 677C>T polymorphism and blood folate concentrations: a systematic review and meta-analysis of trials and observational studies - 2015


Folate, folic acid and 5-methyltetrahydrofolate are not the same thing - 2014

University of Milan

High concentrations of folate and unmetabolized folic acid in a cohort of pregnant Canadian women and umbilical cord blood - 2015

University of Toronto

[6S]-5-methyltetrahydrofolate increases plasma folate more effectively than folic acid in women with the homozygous or wild-type 677C,T polymorphism of methylenetetrahydrofolate reductase - 2009

University of Bonn

Folates, compositions and uses thereof - 2011

Gnosis S.p.A.

There are 22,610 studies on Folate and counting

Substantiation is a living, breathing thing. We are constantly reviewing new research. Have a study you think we should take a look at? Send it our way: