Essential Ingredients

Meet Gnosis, our Folate Producer

5 min read

Article Content

What’s the difference between Folic Acid and Folate?

Folic Acid is synthetically produced, and used in fortified foods and supplements because it can be converted into Folate in the body. To be used, it must be converted to tetrahydrofolate (tetrahydrofolic acid). Increasing evidence suggests that this process may be slow in humans, especially people with a particular genetic mutation (more on that shortly). Conversely, folates occur naturally in many foods and are especially plentiful in dark green leafy vegetables, and they work directly in the body. Our Quatrefolic® is already in a biologically active form, so it can be efficiently utilized even by people who have the gene mutation.*

It’s estimated that roughly one-third of people have the gene mutation that makes it difficult to efficiently utilize folic acid. Can you tells us more about it?

Some people have a genetic mutation, or polymorphism, that hinders their body from efficiently converting dietary or supplemental Folate to its usable form, methylfolate. If you test positive for MTFHR, the solution is for your Folate supplement to be in the active form so your body does not have to convert it – called L-methylfolate.*

For the general population, why is Folate so important?

The human body needs Folate to methylate DNA as well as to act as a cofactor in certain biological reactions. It is especially important in supporting cell division and supporting normal energy-yielding metabolism.*

Why do we find Folic Acid in so many government recommendations and supplement ingredient lists?

Folic Acid is a water-soluble vitamin. It dissolves in water and is not stored in your fat cells. This means that you need to keep taking Folate as your body cannot develop a reserve. And unfortunately, there are a lot of ways people can fall short.*

What makes Quatrefolic® different from other Folate?

There are big variations in how efficiently Folic Acid and Folate is converted to the bioactive form in different people due to the MTHFR call-out I mentioned. Quatrefolic® bypasses the MTHFR conversion step and delivers a "finished" Folate the body can efficiently use at the cellular level.*


Shop Multivitamin


Shop Gut Health

Gut Health

Shop Protein


Shop Pregnancy


Related Articles

See All Articles