Found InLentils, avocado, and oranges
Form6S-5-methyltetrahydrofolate, Glucosamine Salt
SourceSalt, Phenylethylamine and Glucosamine
Final Location of ManufacturingPisticci, Italy
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DNA Methylation*

Energy- Yielding Metabolism*

Our methylated folate is the active, cell-identical form that can bypass common gene variations that make the folic acid to folate conversion more difficult for up to one-third of people.*

Folate and Choline help support neural tube development.*



Evidence-Based or Bust

We use nutrients backed by a significant body of research that is growing every day. Of the thousands of unaffiliated studies our in-house scientists sorted through to guide our choices, the titles below are some relevant MVPs.

Foods, fortificants, and supplements: where do Americans get their nutrients? - 2011

Nutrition Impact LLC

Neural tube defects, folic acid and methylation - 2013

VU Free University

Assessing the association between the methylenetetrahydrofolate reductase (MTHFR) 677C>T polymorphism and blood folate concentrations: a systematic review and meta-analysis of trials and observational studies - 2015


Folate, folic acid and 5-methyltetrahydrofolate are not the same thing - 2014

University of Milan

High concentrations of folate and unmetabolized folic acid in a cohort of pregnant Canadian women and umbilical cord blood - 2015

University of Toronto

[6S]-5-methyltetrahydrofolate increases plasma folate more effectively than folic acid in women with the homozygous or wild-type 677C,T polymorphism of methylenetetrahydrofolate reductase - 2009

University of Bonn

Folates, compositions and uses thereof - 2011

Gnosis S.p.A.

There are 22,610 studies on Folate and counting

Substantiation is a living, breathing thing. We are constantly reviewing new research. Have a study you think we should take a look at? Send it our way: [email protected]

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