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600 mcg

  • Mood*
  • DNA synthesis*
  • Brain Health*
Adequate (40%-80%)

Why Our Form

Our enzymatically active and cell-identical 5MTHF folate is the optimal form.

Vitamins work together

Vitamin B12
Works together to support heart health by adding methyl groups to homocysteine.

Found in

Lentils, avocado, and oranges.

Evidence-Based or Bust

We use nutrients backed by a significant body of research that is growing every day. Of the thousands of unaffiliated studies our in-house scientists sorted through to guide our choices, the titles below are the most relevant MVPs.

Foods, fortificants, and supplements: where do Americans get their nutrients? - 2011

Neural tube defects, folic acid and methylation - 2013

Assessing the association between the methylenetetrahydrofolate reductase (MTHFR) 677C>T polymorphism and blood folate concentrations: a systematic review and meta-analysis of trials and observational studies - 2015

Folate, folic acid and 5-methyltetrahydrofolate are not the same thing - 2014

High concentrations of folate and unmetabolized folic acid in a cohort of pregnant Canadian women and umbilical cord blood - 2015

[6S]-5-methyltetrahydrofolate increases plasma folate more effectively than folic acid in women with the homozygous or wild-type 677C,T polymorphism of methylenetetrahydrofolate reductase - 2009

Folates, compositions and uses thereof - 2011

There are 22,610 studies on Folate and counting

Substantiation is a living, breathing thing. We are constantly reviewing new research. Have a study you think we should take a look at? Send it our way:

Only what you need,
Nothing you don’t

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